منابع مشابه
Blood coagulation dynamics in haemostasis.
Our studies involve computational simulations, a reconstructed plasma/platelet proteome, whole blood in vitro and blood exuding from microvascular wounds. All studies indicate that in normal haemostasis, the binding of tissue factor (TF) with plasma factor (F) VIIa (extrinsic FXase complex) results in the initiation phase of the procoagulant response. This phase is negatively regulated by tissu...
متن کاملBlood coagulation and haemostasis: a review.
FnOM THE V~Y F_~aLY STUVmS of this subject, many controversies existed regarding the various factors and mechanisms involved in the dotting process. One simply has to review the current literature and note the complex, often variable terminology, and the differing opinions of several workers in this field to realize that many of the former controversies are still present. However, many facts ha...
متن کاملBlood Coagulation, Fibrinolysis and Cellular Haemostasis Introduction
A high plasma concentration of coagulation factor VIII (FVIII) is an important risk factor for venous thromboembolism (VTE) (1-4). In the Leiden Thrombophilia study for example, FVIII levels above 1500 IU/L conferred an almost 5-fold risk for a first episode of deep-vein thrombosis (1). Most importantly, high FVIII is also associated with a very high risk of recurrent venous thromboembolism (4,...
متن کاملFlow dynamics and haemostasis.
Fluid-dynamic conditions that are compatible with tensile stress on the bonds between platelet glycoprotein Ibalpha and immobilized Von Willebrand factor A1 domain (VWF-A1) led to Ca++ release from intracellular stores (type alpha/beta peaks), which preceded stationary platelet adhesion. Raised levels of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate inhibited these [C...
متن کاملErythrocytes, haemostasis, and coagulation monitoring in postpartum haemorrhage (PPH).
haemoglobin concentration required to aid haemostasis is unclear targeting a level of 7–9 g dl has been suggested. Thus interpretation of VEM results in conjunction with the haemoglobin level and platelet count empowers the clinician to make appropriate decisions regarding further blood component therapy. Haemostatic resuscitation and monitoring is in the midst of a paradigm shift. The treatmen...
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ژورنال
عنوان ژورنال: Hämostaseologie
سال: 2009
ISSN: 0720-9355,2567-5761
DOI: 10.1055/s-0037-1616932